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陈清云医生

乳腺外科资深顾问医生
MBChB (Edin), FRCS (Edin), FRCS (Glas), PhD (Bristol)
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作为我们的资深顾问,陈清云医生对癌症的形成以及如何抑制和治疗癌症有浓厚的兴趣。自2009年起,陈医生开始担任新加坡国立大学Yong Loo Lin医学院的助理教授。在加入暄晖之前,她是新加坡国立大学卫生系统乳腺专业的负责人,陈医生还是新加坡国立癌症研究所乳腺肿瘤学项目组的负责人。

教育经历和资质

陈医生取得爱丁堡大学医学学位后,在新加坡中央医院完成了普外的基础和高级专业培训,并于2007年退出该项目组。1999年起,她成为爱丁堡皇家外科医学院和格拉斯哥皇家内科医学院的院士。在接受外科培训期间,陈医生获得了NMRC Totalisator委员会奖学金,并于2004年在布里斯托大学获得神经内分泌学博士学位。

荣获HMDP奖和技能见习奖

2008年,陈医生作为英国诺丁汉乳腺研究所乳腺肿瘤整形研究员获得了卫生人力发展项目 (HMDP) 奖。她接受了治疗性隆胸术、背阔肌皮瓣用于部分和全部乳房重建术、移植重建术、双侧对称手术,以及用于体积不足和轮廓重复的脂肪移植等手术方法的培训。此外,陈医生还帮助开展了针对癌症诊断、检测和治疗各个方面的过渡性研究。

在不断追求自己的兴趣和受教育过程中,她还于2018年获得了对比增强乳腺X光 (AMDA团队奖) 的技能见习奖。

阅读陈清云医生的文章
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陈清云医生的医学刊物

Optoacoustic characterization of breast conserving surgery specimens – A pilot study. PHOTOACOUSTICS, 19, 9 pages (2020)
G. Balasundaram, Goh, Y., Moothanchery. M, Attia, A., Lim, H.Q., Burton, N. C., Olivo, M., Chan, C.W.

Maintaining breast cancer care in the face of COVID-19. British Journal of Surgery, 107(10), 1245-1249 (2020)
Ng, C. W. Q., Tseng, M., Lim, J. S. J., & Chan, C. W.

European polygenic risk score for prediction of breast cancer shows similar performance in Asian women. NATURE COMMUNICATIONS, 11(1), 11 pages (2020)
Ho, W. K., Tan, M. M., Mavaddat, N., Tai, M. C., Mariapun, S., Li, J., Antoniou, A. C., Chan, C. W.

Ultrasound Guided Optoacoustic Tomography in Assessment of Tumor Margins for Lumpectomies. TRANSLATIONAL ONCOLOGY, 13(2), 254-261 (2020)
Goh, Y., Balasundaram, G., Moothanchery, M., Attia, A., Li, X., Lim, H. Q., Olivo, M., Chan, C. W.

Barcoded DNA nanostructures for the multiplexed profiling of subcellular protein distribution.. Nat Biomed Eng, 3(9), 684-694 (2019)
Sundah, N. R., Ho, N. R. Y., Lim, G. S., Natalia, A., Ding, X., Liu, Y., Shao, H., Chan, C. W.

The functional ALDH2 polymorphism is associated with breast cancer risk: A pooled analysis from the Breast Cancer Association Consortium. Molecular Genetics and Genomic Medicine, 7(6) (2019)
Ugai, T., Milne, R. L., Ito, H., Aronson, K. J., Bolla, M. K., Chan, T., Matsuo, K., Chan, C. W.

Investing in gender equity in health and biomedical research: a Singapore perspective. LANCET, 393(10171), E21-E22 (2019)
Yoong, J., Alonso, S., Chan, C. W., Clement, M. V., Lim, L. H. K., & Archuleta, S.

Multispectral Optoacoustic Tomography in Assessment of Breast Tumor Margins During Breast-Conserving Surgery: A First-in-human Case Study. CLINICAL BREAST CANCER, 18(6), E1247-E1250 (2018)
Goh, Y., Balasundaram, G., Moothanchery, M., Attia, A., Li, X., Lim, H. Q., Olivo, M., Chan, C. W.

A genome-wide association study identifies three novel genetic markers for response to tamoxifen: A prospective multicenter study. PLOS ONE, 13(8), 14 pages (2018)
Onishi, H., Udagawa, C., Kubo, M., Nakamura, S., Akashi-Tanaka, S., Kuwayama, T., Zembutsu, H., Chan, C. W.

Ductal carcinoma in-situ arising within benign phyllodes tumours. ANNALS OF THE ROYAL COLLEGE OF SURGEONS OF ENGLAND, 100(4), E97-E102 (2018)
Lui, S. A., Oh, H. B., Wang, S., & Chan, C. W.

Triple negative breast cancer in Asia: An insider’s view. CANCER TREATMENT REVIEWS, 62, 29-38 (2018)
Wang, C., Kar, S., Lai, X., Cai, W., Arfuso, F., Sethi, G., Kumar, A. P., Chan, C. W.

Significant Effect of Polymorphisms in CYP2D6 on Response to Tamoxifen Therapy for Breast Cancer: A Prospective Multicenter Study. CLINICAL CANCER RESEARCH, 23(8), 2019-2026 (2017)
Zembutsu, H., Nakamura, S., Akashi-Tanaka, S., Kuwayama, T., Watanabe, C., Takamaru, T., Nakamura, Y. , Chan, C. W.

Genomic predictors of neoadjuvant chemotherapy (NACT) response in breast cancer (BC).. In JOURNAL OF CLINICAL ONCOLOGY Vol. 35 (pp. 5 pages). Chicago, IL: AMER SOC CLINICAL ONCOLOGY (2017)
Wong, A. L. A., Tan, K. T., Sundar, R., Ow, S., Pang, A., Yap, H. -L., Lee, S. C., Chan, C. W.

Phase Ib/II randomized, open-label study of doxorubicin and cyclophosphamide with or without low-dose, short-course sunitinib in the pre-operative treatment of breast cancer. ONCOTARGET, 7(39), 64089-64099 (2016)
Wong, A. L. A., Sundar, R., Wang, T. -T., Ng, T. C., Zhang, B., Tan, S. H., Lee, S. C., Chan, C. W.

High expression of intratumoral stromal proteins is associated with chemotherapy resistance in breast cancer. ONCOTARGET, 7(34), 55155-55168 (2016)
Wang, T., Srivastava, S., Hartman, M., Buhari, S. A., Chan, C. W., Iau, P., Lee, S. C.

Considerations regarding lipofilling in patients after breast cancer. JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY, 69(5), E103-E104 (2016)
Chan, C. W.

Simvastatin-induced breast cancer cell death and deactivation of PI3K/Akt and MAPK/ERK signalling are reversed by metabolic products of the mevalonate pathway. ONCOTARGET, 7(3), 2532-2544 (2016)
Wang, T., Seah, S., Loh, X., Chan, C. W., Hartman, M., Goh, B. C., & Lee, S. C.

Accelerated partial breast irradiation in an Asian population: dosimetric findings and preliminary results of a multicatheter interstitial program. ONCOTARGETS AND THERAPY, 9, 5561-5566 (2016)
Koh, Y. V., Tan, P. W., Buhari, S. A., Iau, P., Chan, C. W., Shen, L., Tang, J. I. H., Chan, C. W.

Genomic landscapes of breast fibroepithelial tumors. NATURE GENETICS, 47(11), 1341-+ (2015)
Tan, J., Ong, C. K., Lim, W. K., Ng, C. C. Y., Thike, A. A., Ng, L. M., Teh, B. T., Chan, C. W.

Cell viability and angiogenic potential of a bioartificial adipose substitute. JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, 9(6), 702-713 (2015)
Panneerselvan, A., Nguyen, L. T. H., Su, Y., Teo, W. E., Liao, S., Ramakrishna, S., & Chan, C. W.

Differential cell adhesion of breast cancer stem cells on biomaterial substrate with nanotopographical cues.. J Funct Biomater, 6(2), 241-258 (2015)
Tan, K. K. B., Giam, C. S. Y., Leow, M. Y., Chan, C. W., & Yim, E. K. F., Chan, C. W.

Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer. NATURE GENETICS, 47(4), 373-U127 (2015)
Michailidou, K., Beesley, J., Lindstrom, S., Canisius, S., Dennis, J., Lush, M. J., Easton, D. F., Chan, C. W.

Common non-synonymous SNPs associated with breast cancer susceptibility: findings from the Breast Cancer Association Consortium. HUMAN MOLECULAR GENETICS, 23(22), 6096-6111 (2014)
Milne, R. L., Burwinkel, B., Michailidou, K., Arias-Perez, J. I., Pilar Zamora, M., Menendez-Rodriguez, P., .Easton, D. F., Chan, C. W.

Simvastatin induced apoptosis and suppressed proliferation of breast cancer through deactivating PI3K/Akt/mTOR pathway. In CANCER RESEARCH Vol. 74 (pp. 2 pages). San Diego, CA: AMER ASSOC CANCER RESEARCH (2014)
Wang, T., Seah, S., Chan, C. W., Hartman, M., Dar, N. N. T., Iau, P., Lee, S. C.

Phase II study of neoadjuvant weekly paclitaxel and carboplatin with lapatinib in HER2+breast cancer.. In JOURNAL OF CLINICAL ONCOLOGY Vol. 32 (pp. 1 page). Chicago, IL: AMER SOC CLINICAL ONCOLOGY (2014)
Wong, A. L. A., Tan, S. H., Soh, I. P. T., Tan, C. S., Lim, Y. W., Pang, A., Lee, S. C., Chan, C. W.

Effect of low-dose, short-course sunitinib (Su) on tumor vasculature and tumor blood flow for enhancement of chemotherapy efficacy in breast cancer.. In JOURNAL OF CLINICAL ONCOLOGY Vol. 32 (pp. 1 page). Chicago, IL: AMER SOC CLINICAL ONCOLOGY (2014)
Wong, A. L. A., Sundar, R., Ow, S. G. W., Wang, T. T., Ng, T. -C., Chan, C. W., Lee, S. C.

Genome-wide association studies identify four ER negative-specific breast cancer risk loci. NATURE GENETICS, 45(4), 392-398 (2013)
Garcia-Closas, M., Couch, F. J., Lindstrom, S., Michailidouo, K., Schmidt, M. K., Brook, M. N., Kraft, P., Chan, C. W.

Low-dose, short-course sunitinib may normalize tumor vasculature and improve tumor blood flow to enhance chemotherapy efficacy in breast cancers. In JOURNAL OF CLINICAL ONCOLOGY Vol. 30 (pp. 1 page). Chicago, IL: AMER SOC CLINICAL ONCOLOGY (2012)
Lee, S. -C., Wong, A. L. A., Ng, T. C., Thng, C. H., Wang, T. T., Tiemsim, M. C., Goh, B. C., Chan, C. W.

Extracellular matrix protein expression is associated with chemotherapy resistance in breast cancer. In CANCER RESEARCH Vol. 72 (pp. 1 page). AMER ASSOC CANCER RESEARCH (2012)
Wang, T., Guo, T., Sze, S. K., Hartman, M., Buhari, S. A., Chan, C. W., Lee, S. C.

Serial changes in the expression of breast cancer-related proteins in response to neoadjuvant chemotherapy. ANNALS OF ONCOLOGY, 22(8), 1748-1754 (2011)
Chuah, B. Y. S., Putti, T., Salto-Tellez, M., Charlton, A., Iau, P., Buhari, S. A., Lee, S. C., Chan, C. W.

A Commentary on Delayed Presentation of Breast Cancer in Singapore. ASIAN PACIFIC JOURNAL OF CANCER PREVENTION, 12(6), 1635-1639 (2011)
Chang, G., Chan, C. W., & Hartman, M.

Pharmacokinetics and pharmacodynamics of docetaxel with or without ketoconazole modulation in chemonaive breast cancer patients. ANNALS OF ONCOLOGY, 21(11), 2175-2182 (2010)
Lim, Y. -W., Goh, B. C., Wang, L. Z., Tan, S. H., Chuah, B. Y. S., Lim, S. E., Lee, S. C., Chan, C. W.

Autologous fat transfer – a review of the literature with a focus on breast cancer surgery. Journal of Plastic, Reconstructive and Aesthetic Surgery, 61(12), 1438-1448 (2008)
Chan, C. W., McCulley, S. J., & Macmillan, R. D.

Volume displacement techniques and therapeutic mammoplasty: The Nottingham experience. Advances in Breast Cancer, 5(1), 10-12 (2008)
Macmillan, R. D., Chan, C. W., & McCulley, S. J.

A novel member of the SAF (scaffold attachment factor)-box protein family inhibits gene expression and induces apoptosis. Biochemical Journal, 407(3), 355-362 (2007)
Chan, C. W., Lee, Y. B., Uney, J., Flynn, A., Tobias, J. H., & Norman, M.